Also, we are targeting enzymes involved in gluconeogenesis and glycolysis with small molecule FDA-approved antimetabolites to achieve antitumor effects. We are testing the utility of differentiation therapy through reactivating RAR-beta in breast cancer using histone deacetylase inhibitors with great success. In addition, epigenetically silenced genes and a metabolic reprogramming in tumors also trigger novel early detection and therapeutic strategies. Our work explores the alternate pathways that are activated by HOX proteins leading to this resistance and novel treatments to overcome resistance in both tissue culture and xenograft models. RAR files, you’ll want to extract the first file in the. Note that if you’ve got a multi-part set of. Right-click any RAR file, point to the 7-Zip menu, and then select one of the Extract options, depending on where you want to extract the files. HOX genes are intimately involved in the development of resistance to both chemotherapy and to agents targeting the estrogen receptor. If you know you want to extract the files, you can do it without even opening 7-Zip. Among deferentially expressed genes, our lab has focused on the HOX genes. Our lab is focused on using comprehensive gene expression, methylation and sequencing and metabolomics analysis to identify alterations in breast cancer, and exploiting these for early detection and therapy. Principal Investigator: Saraswati Sukumar, Ph.D.
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